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KMID : 0869220100140010020
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Journal of Korean Geriatric Psychiatry
2010 Volume.14 No. 1 p.20 ~ p.26
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An Association Study between Various Adrenergic Alpha 2 Receptor Polymorphisms and Treatment Response to Mirtazapine in Major Depression
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Kim Jin-Woo
Lim Shinn-Won
Choi Hong
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Abstract
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Objectives: Genetic differences may contribute to the inter-individual differences in treatment response to antidepressants among
patients suffering from major depression. This study investigated a possible association of treatment response to mirtazapine with various
adrenergic alpha 2 receptor polymorphisms in major depressive patients.
Methods: A 6-week naturalistic treatment study with a blinded outcome examined 84 Korean patients with major depression.
Treatment response to mirtazapine was defined as ≥50% decrease in HAM-D scores at six weeks. In this study, four genetic polymorphisms
were selected；ADRA2A MspI, ADRA2A DraI, α2BDel301-303, andα2CDel322-325.
Results: The Del/Del genotype of α2CDel322-325 exhibited a significant association with response to mirtazapine through multiple
logistic regression. ADRA2A DraI, α2BDel301-303, and α2CDel322-325 did not showed a significant association with response
to mirtazapine.
Conclusion: Based on the finding that α2CDel322-325 polymorphism had an association with the mirtazapine response, we postulate
that the polymorphism related to the mechanism of the antidepressant effect is important in predicting the response to antidepressants.
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KEYWORD
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Mirtazapine·Single nucleotide polymorphism·Pharmacogenetics·Major depression·Adrenergic receptor.
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